He was the title star of a short-lived UPN sitcom called DiResta from 1998-1999. He has appeared in several films, including Miss Congeniality and its sequel, Miss Congeniality 2: Armed and Fabulous, as well as on the CBS sitcom Rules of Engagement. In 2004 he got a show on FX called Trash to Cash where he and his brother Jimmy Diresta went around buying or finding cheap garbage. Jimmy would build whatever was needed and John act as the comic relief. It lasted one season. He co-hosted a show with his brother on HGTV. Hammered with John and Jimmy DiResta (premiered September 16, 2006). Jimmy DiResta, an inventor and carpenter, builds intricate projects while John, similar to previous programs, acts as the comic foil. Hammered aired for two seasons. John also stars as "Johnny" in an American Chopper spoof series called American Body Shop on Comedy Central that began airing in 2007.
John grew up in the Five Towns area of Long Island, with two brothers, Jimmy DiResta and Joe DiResta, and one sister and graduated from Hewlett High School in 1982. Several years ago, he was inducted into the school's hall of fame.